The Antibiotic Trimethoprim Displays Strong Mutagenic Synergy with 2-Aminopurine

We show that trimethoprim (TMP), an antibiotic in current use, displays a strong synergistic effect on mutagenesis in Escherichia coli when paired with the base analog 2-aminopurine (2AP), resulting in a 35-fold increase in mutation frequencies in the rpoB-Rif(r) system. Combination therapies are of...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: D’Souza, Sara, Miller, Justin E., Ahn, Jenny, Subandi, Raechel, Lozano, Daniel, Ramirez, James, Goff, Marisa, Davidian, Christina, Miller, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355555/
https://ncbi.nlm.nih.gov/pubmed/30509944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01577-18
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