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SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension
Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPR(mt)). A cascade of events occur upon UPR(mt) activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific...
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| Vydáno v: | eLife |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
eLife Sciences Publications, Ltd
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355198/ https://ncbi.nlm.nih.gov/pubmed/30642431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41792 |
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