Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells

Mouse embryonic stem cells (mESCs) are pluripotent and can differentiate into cells belonging to the three germ layers of the embryo. However, mESC pluripotency and genome stability can be compromised in prolonged in vitro culture conditions. Several factors control mESC pluripotency, including Wnt/...

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Publié dans:Sci Rep
Auteurs principaux: Theka, Ilda, Sottile, Francesco, Cammisa, Marco, Bonnin, Sarah, Sanchez-Delgado, Marta, Di Vicino, Umberto, Neguembor, Maria Victoria, Arumugam, Karthik, Aulicino, Francesco, Monk, David, Riccio, Andrea, Cosma, Maria Pia
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353868/
https://ncbi.nlm.nih.gov/pubmed/30700782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37442-5
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