REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

OBJECTIVES: The release of neutrophil extracellular traps (NETs) represents a novel neutrophil effector function in systemic lupus erythematosus (SLE) pathogenesis. However, the molecular mechanism underlying NET release and how NETs mediate end-organ injury in SLE remain elusive. METHODS: NET forma...

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Dades bibliogràfiques
Publicat a:Ann Rheum Dis
Autors principals: Frangou, Eleni, Chrysanthopoulou, Akrivi, Mitsios, Alexandros, Kambas, Konstantinos, Arelaki, Stella, Angelidou, Iliana, Arampatzioglou, Athanasios, Gakiopoulou, Hariklia, Bertsias, George K, Verginis, Panayotis, Ritis, Konstantinos, Boumpas, Dimitrios T
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2019
Matèries:
Systemic Lupus Erythematosus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352428/
https://ncbi.nlm.nih.gov/pubmed/30563869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213181
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