Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome

BACKGROUND: The phosphatidylinositol 3-kinase delta isoform (PI3Kδ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation, apoptosis and migration and has been successfully targeted in B-cell malignancies. Primary Sjögren’s syndrome (pSS) is a c...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Nayar, Saba, Campos, Joana, Smith, Charlotte G, Iannizzotto, Valentina, Gardner, David H, Colafrancesco, Serena, Pipi, Elena, Kollert, Florian, Hunter, Kelly J, Brewer, Charlotte, Buckley, Christopher Dominic, Bowman, Simon J, Priori, Roberta, Valesini, Guido, Juarez, Maria, Fahy, William A, Fisher, Benjamin A, Payne, Andrew, Allen, Rodger A, Barone, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Sjögren's Syndrome
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352416/
https://ncbi.nlm.nih.gov/pubmed/30472652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2017-212619
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