RanGAP‐mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain

By the end of neurogenesis in Drosophila pupal brain neuroblasts (NBs), nuclear Prospero (Pros) triggers cell cycle exit and terminates NB lifespan. Here, we reveal that in larval brain NBs, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran‐mediated n...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Wu, Di, Wu, Litao, An, Huanping, Bao, Hongcun, Guo, Pengfei, Zhang, Bei, Zheng, Huimei, Zhang, Fan, Ge, Wanzhong, Cai, Yu, Xi, Yongmei, Yang, Xiaohang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351831/
https://ncbi.nlm.nih.gov/pubmed/30549175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12854
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