Lineage tracing of Notch1-expressing cells in intestinal tumours reveals a distinct population of cancer stem cells

Colon tumours are hierarchically organized and contain multipotent self-renewing cells, called Cancer Stem Cells (CSCs). We have previously shown that the Notch1 receptor is expressed in Intestinal Stem Cells (ISCs); given the critical role played by Notch signalling in promoting intestinal tumourig...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mourao, Larissa, Jacquemin, Guillaume, Huyghe, Mathilde, Nawrocki, Wojciech J., Menssouri, Naoual, Servant, Nicolas, Fre, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351556/
https://ncbi.nlm.nih.gov/pubmed/30696875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37301-3
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