γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity

L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the enzyme γ-glutamyltr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Corti, Alessandro, Dominici, Silvia, Piaggi, Simona, Belcastro, Eugenia, Chiu, Martina, Taurino, Giuseppe, Pacini, Simone, Bussolati, Ovidio, Pompella, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351548/
https://ncbi.nlm.nih.gov/pubmed/30696905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37385-x
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