Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD

OBJECTIVES: The combination of high YKL-40 (a glial inflammatory marker) and low sAPPβ (a soluble β fragment of amyloid precursor protein) in cerebrospinal fluid (CSF) has been associated with frontotemporal lobar degeneration (FTLD) in clinical series. We investigate these biomarkers in a neuropath...

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Detalhes bibliográficos
Publicado no:J Neurol Neurosurg Psychiatry
Main Authors: Alcolea, Daniel, Irwin, David J, Illán-Gala, Ignacio, Muñoz, Laia, clarimón, Jordi, McMillan, Corey T, Fortea, Juan, Blesa, Rafael, Lee, Edward B, Trojanowski, John Q, Grossman, Murray, Lleó, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351153/
https://ncbi.nlm.nih.gov/pubmed/30297518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2018-318993
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