Estrogen-Independent Myc Overexpression Confers Endocrine Therapy Resistance on Breast Cancer Cells Expressing ERαY537S and ERαD538G Mutations

Approximately 30% of metastatic breast cancers harbor estrogen receptor α (ERα) mutations associated with resistance to endocrine therapy and reduced survival. Consistent with their constitutive proliferation, T47D and MCF7 cells in which wild-type ERα is replaced by the most common mutations, ERαY5...

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Udgivet i:Cancer Lett
Main Authors: Yu, Liqun, Wang, Lawrence, Mao, Chengjian, Duraki, Darjan, Kim, Ji Eun, Huang, Rui, Helferich, William G., Nelson, Erik R., Park, Ben Ho, Shapiro, David J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351074/
https://ncbi.nlm.nih.gov/pubmed/30419347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.10.041
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