APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy

Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance. PD-L1/PD-1 checkpoint immunotherapy is a highly promising approach to overcome these protective sig...

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Vydáno v:Oncoimmunology
Hlavní autoři: Boichard, Amélie, Pham, Timothy V., Yeerna, Huwate, Goodman, Aaron, Tamayo, Pablo, Lippman, Scott, Frampton, Garrett M., Tsigelny, Igor F., Kurzrock, Razelle
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350681/
https://ncbi.nlm.nih.gov/pubmed/30723579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1550341
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