Myelin basic protein charge isomers change macrophage polarization

PURPOSE: During a neuronal injury, a variety of immune cells infiltrate into the local microenvironment at the demyelination site. After the destruction of the intact myelin sheath, its major constituent myelin basic protein (MBP) dissociates from the plasma membrane and acts as a free ligand on the...

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Bibliographic Details
Published in:J Inflamm Res
Main Authors: Tsitsilashvili, Elene, Sepashvili, Maia, Chikviladze, Marika, Shanshiashvili, Lali, Mikeladze, David
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350649/
https://ncbi.nlm.nih.gov/pubmed/30774410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S189570
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