Metformin Counteracts HCC Progression and Metastasis Enhancing KLF6/p21 Expression and Downregulating the IGF Axis

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is the common tumor of the liver. Unfortunately, most HCC seem to be resistant to conventional chemotherapy and radiotherapy. The poor efficacy of antitumor agents is also due, at least in part, to the inefficient drug delivery and metabolism exert...

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Vydáno v:Int J Endocrinol
Hlavní autoři: Vacante, Fernanda, Senesi, Pamela, Montesano, Anna, Paini, Stefano, Luzi, Livio, Terruzzi, Ileana
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350585/
https://ncbi.nlm.nih.gov/pubmed/30774659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7570146
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