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Fatty Acids Compete with Aβ in Binding to Serum Albumin by Quenching Its Conformational Flexibility
Human serum albumin (HSA) has been identified as an important regulator of amyloid-β (Aβ) fibrillization both in blood plasma and in cerebrospinal fluid. Fatty acids bind to HSA, and high serum levels of fatty acids increase the risk of Alzheimer’s disease. In vitro, fatty-acid-loaded HSA (FA·HSA) l...
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| Publicado no: | Biophys J |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6349961/ https://ncbi.nlm.nih.gov/pubmed/30580919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.11.3133 |
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