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High-Throughput Assessment of Structural Continuity in Biologics

[Image: see text] We demonstrate a high-throughput chemoprinting platform that confirms the consistency in the higher-order structure of protein biologics and is sensitive enough to detect single-point mutations. This method addresses the quality and consistency of the tertiary and quaternary struct...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Musetti, Caterina, Bean, Mark F., Quinque, Geoffrey T., Kwiatkowski, Christopher, Szewczuk, Lawrence M., Baldoni, John, Zajac, Matthew A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349355/
https://ncbi.nlm.nih.gov/pubmed/29369625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b00180
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