Oral Selumetinib Does Not Negatively Impact Photoreceptor Survival in Murine Experimental Retinal Detachment

PURPOSE: Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling is neuroprotective in some retinal damage models but its role in neuronal survival during retinal detachment (RD) is unclear. In addition, serous RDs are a prevalent side effect of MEK inhibitors (ME...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Cebulla, Colleen M., Kim, Bongsu, George, Valerie, Heisler-Taylor, Tyler, Hamadmad, Sumaya, Reese, Alana Y., Kothari, Shaili S., Kusibati, Rania, Wilson, Hailey, Abdel-Rahman, Mohamed H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2019
Assuntos:
Anatomy and Pathology/Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348998/
https://ncbi.nlm.nih.gov/pubmed/30682205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.18-25405
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