Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid-β (Aβ) deposition, which leads to lobar hemorrhage and dementia. Biological molecules affecting the development of CAA have not been fully characterized. In this study, we performed proteome analysis of biopsied l...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Endo, Yoshinori, Hasegawa, Kazuhiro, Nomura, Ryo, Arishima, Hidetaka, Kikuta, Ken-ichiro, Yamashita, Taro, Inoue, Yasuteru, Ueda, Mitsuharu, Ando, Yukio, Wilson, Mark R., Hamano, Tadanori, Nakamoto, Yasunari, Naiki, Hironobu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348632/
https://ncbi.nlm.nih.gov/pubmed/30691533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0662-1
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