Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin

We report crystal structures of the antibacterial lasso peptides microcin J25 (MccJ25) and capistruin (Cap) bound to their natural enzymatic target, the bacterial RNA polymerase (RNAP). Both peptides bind within the RNAP secondary channel, through which NTP substrates enter the RNAP active site, and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Braffman, Nathaniel R., Piscotta, Frank J., Hauver, Jesse, Campbell, Elizabeth A., Link, A. James, Darst, Seth A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347699/
https://ncbi.nlm.nih.gov/pubmed/30626643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817352116
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