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Reduced expression of the ferroptosis inhibitor GPx4 in multiple sclerosis and experimental autoimmune encephalomyelitis
Glutathione peroxidase 4 (GPx4) is the only enzyme capable of reducing toxic lipid hydroperoxides in biological membranes to the corresponding alcohols using GSH as the electron donor. GPx4 is the major inhibitor of ferroptosis, a non-apoptotic and iron-dependent programmed cell death pathway, which...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6347488/ https://ncbi.nlm.nih.gov/pubmed/30289974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14604 |
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