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Iba-1(-)/CD68(+) microglia are a prominent feature of age-associated deep subcortical white matter lesions

Deep subcortical lesions (DSCL) of the brain, are present in ~60% of the ageing population, and are linked to cognitive decline and depression. DSCL are associated with demyelination, blood brain barrier (BBB) dysfunction, and microgliosis. Microglia are the main immune cell of the brain. Under phys...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Waller, Rachel, Baxter, Lynne, Fillingham, Daniel J., Coelho, Santiago, Pozo, Jose M., Mozumder, Meghdoot, Frangi, Alejandro F., Ince, Paul G., Simpson, Julie E., Highley, J. Robin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347230/
https://ncbi.nlm.nih.gov/pubmed/30682074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210888
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