Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

BACKGROUND: Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In Plasmodium, a bifunctional enzyme named glucose 6-phosphate...

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Detalhes bibliográficos
Publicado no:Malar J
Main Authors: Haeussler, Kristina, Berneburg, Isabell, Jortzik, Esther, Hahn, Julia, Rahbari, Mahsa, Schulz, Norma, Preuss, Janina, Zapol’skii, Viktor A., Bode, Lars, Pinkerton, Anthony B., Kaufmann, Dieter E., Rahlfs, Stefan, Becker, Katja
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346587/
https://ncbi.nlm.nih.gov/pubmed/30683097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-019-2651-z
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