A randomised controlled trial of a mitochondrial therapeutic target for bipolar depression: mitochondrial agents, N-acetylcysteine, and placebo

BACKGROUND: A phasic dysregulation of mitochondrial bioenergetics may operate in bipolar disorder, increased in mania and decreased in depression. We aimed to examine efficacy of two add-on treatments in bipolar depression: N-acetylcysteine (NAC) and NAC with a combination of nutraceutical agents th...

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Détails bibliographiques
Publié dans:BMC Med
Auteurs principaux: Berk, Michael, Turner, Alyna, Malhi, Gin S., Ng, Chee, Cotton, Susan M., Dodd, Seetal, Samuni, Yuval, Tanious, Michelle, McAulay, Claire, Dowling, Nathan, Sarris, Jerome, Owen, Lauren, Waterdrinker, Astrid, Smith, Deidre, Dean, Olivia M.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6346513/
https://ncbi.nlm.nih.gov/pubmed/30678686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-019-1257-1
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