An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the retrogene encoding RBMXL2 blocks spermatogenesis. Transcriptome analyses of age-matched deletion mice show that RBMXL2 controls splicing patter...

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Pubblicato in:eLife
Autori principali: Ehrmann, Ingrid, Crichton, James H, Gazzara, Matthew R, James, Katherine, Liu, Yilei, Grellscheid, Sushma Nagaraja, Curk, Tomaž, de Rooij, Dirk, Steyn, Jannetta S, Cockell, Simon, Adams, Ian R, Barash, Yoseph, Elliott, David J
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Chromosomes and Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345566/
https://ncbi.nlm.nih.gov/pubmed/30674417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39304
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