Unprecedented inhibition of P-gp activity by a novel rutheniumcyclopentadienyl compound bearing a bipyridine-biotin ligand

Two new ruthenium complexes, [Ru(η(5)-Cp)(PPh(3))(2,2’-bipy-4,4’-R)](+) with R = CH(2)OH (Ru1) or dibiotin ester (Ru2) were synthesized and fully characterized. Both compounds were tested against two types of breast cancer cells (MCF7 and MDA-MB231), showing better cytotoxicity than cisplatin in the...

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Publicado no:Eur J Med Chem
Main Authors: Côrte-Real, Leonor, Karas, Brittany, Gírio, Patrícia, Moreno, Alexis, Avecilla, Fernando, Marques, Fernanda, Buckley, Brian T., Cooper, Keith R., Doherty, Cathleen, Falson, Pierre, Garcia, M. Helena, Valente, Andreia
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345558/
https://ncbi.nlm.nih.gov/pubmed/30579125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.12.022
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