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Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound
Fibrosis is characterized by excessive production of type I collagen. Biosynthesis of type I collagen in fibrosis is augmented by binding of protein LARP6 to the 5′ stem-loop structure (5′SL), which is found exclusively in type I collagen mRNAs. A high throughput screen was performed to discover inh...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344531/ https://ncbi.nlm.nih.gov/pubmed/30674965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36841-y |
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