Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. It is caused by the overexpansion of cytosine-guanine-guanine (CGG) trinucleotide in Fmr1 gene, resulting in complete loss of the fragile X mental retardation protein (FMRP). Previous studies using Fmr1 knockout (...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Yau, Suk-Yu, Bettio, Luis, Chiu, Jason, Chiu, Christine, Christie, Brian R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344420/
https://ncbi.nlm.nih.gov/pubmed/30705620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00495
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