Human endogenous retrovirus-K contributes to motor neuron disease

The role of human endogenous retroviruses (HERVs) in disease pathogenesis is unclear. We show that HERV-K is activated in a subpopulation of patients with sporadic amyotrophic lateral sclerosis (ALS) and that its envelope (env) protein may contribute to neurodegeneration. The virus was expressed in...

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Publicat a:Sci Transl Med
Autors principals: Li, Wenxue, Lee, Myoung-Hwa, Henderson, Lisa, Tyagi, Richa, Bachani, Muzna, Steiner, Joseph, Campanac, Emilie, Hoffman, Dax A., von Geldern, Gloria, Johnson, Kory, Maric, Dragan, Morris, H. Douglas, Lentz, Margaret, Pak, Katherine, Mammen, Andrew, Ostrow, Lyle, Rothstein, Jeffrey, Nath, Avindra
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344353/
https://ncbi.nlm.nih.gov/pubmed/26424568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aac8201
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