Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5

Tumor-associated blood vessels and lymphatics are abnormal and dysfunctional. These are hallmarks of the tumor microenvironment, which has an immunosuppressive nature, such as through hypoxia. Treatment with anti-death receptor5 (DR5) monoclonal antibody MD5-1, which induces tumor cell death, is a p...

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Bibliographische Detailangaben
Veröffentlicht in:Oncoimmunology
Hauptverfasser: Tsukita, Yoko, Okazaki, Tatsuma, Ebihara, Satoru, Komatsu, Riyo, Nihei, Mayumi, Kobayashi, Makoto, Hirano, Taizou, Sugiura, Hisatoshi, Tamada, Tsutomu, Tanaka, Nobuyuki, Sato, Yasufumi, Yagita, Hideo, Ichinose, Masakazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343781/
https://ncbi.nlm.nih.gov/pubmed/30713805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1543526
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