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Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation
Antibiotic resistance is often the result of mutations that block drug activity; however, bacteria also evade antibiotics by transiently expressing genes such as multidrug efflux pumps. A crucial question is whether transient resistance can promote permanent genetic changes. Previous studies have es...
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| Gepubliceerd in: | Science |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6343669/ https://ncbi.nlm.nih.gov/pubmed/30409883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar7981 |
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