Live attenuated influenza vaccine viral vector induces functional cytotoxic T-cell immune response against foreign CD8+ T-cell epitopes inserted into NA and NS1 genes using the 2A self-cleavage site

The development of viral vector vaccines against various pathogens for which conventional vaccination approaches are not applicable has been a priority for a number of years. One promising approach is the insertion of immunodominant conservative cytotoxic T-cell (CTL) epitopes into the genome of a v...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Hum Vaccin Immunother
Hauptverfasser: Kotomina, Tatiana, Korenkov, Daniil, Matyushenko, Victoria, Prokopenko, Polina, Rudenko, Larisa, Isakova-Sivak, Irina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Short Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343631/
https://ncbi.nlm.nih.gov/pubmed/30024831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2018.1502529
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