Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils

Bone marrow-derived myeloid cells can accumulate in high numbers within solid tumors and mediate functions that foster cancer outgrowth. Immune-neoplastic interactions in the local tumor microenvironment have been intensively investigated, but the contribution of the host systemic environment to tum...

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Publicado no:Science
Main Authors: Engblom, Camilla, Pfirschke, Christina, Zilionis, Rapolas, Martins, Janaina da Silva, Bos, Stijn A., Courties, Gabriel, Rickelt, Steffen, Severe, Nicolas, Baryawno, Ninib, Faget, Julien, Savova, Virginia, Zemmour, David, Kline, Jaclyn, Siwicki, Marie, Garris, Christopher, Pucci, Ferdinando, Liao, Hsin-Wei, Lin, Yi-Jang, Newton, Andita, Yaghi, Omar K., Iwamoto, Yoshiko, Tricot, Benoit, Wojtkiewicz, Gregory R., Nahrendorf, Matthias, Cortez-Retamozo, Virna, Meylan, Etienne, Hynes, Richard O., Demay, Marie, Klein, Allon, Bredella, Miriam A., Scadden, David T., Weissleder, Ralph, Pittet, Mikael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343476/
https://ncbi.nlm.nih.gov/pubmed/29191879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aal5081
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