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Challenges in Quantifying Cytosine Methylation in the HIV Provirus

DNA methylation is an epigenetic mechanism most commonly associated with transcriptional repression. While it is clear that DNA methylation can silence HIV proviral expression in in vitro latency models, its correlation with HIV persistence and expression in vivo is ambiguous, particularly in person...

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Publicado en:mBio
Main Authors: LaMere, Sarah A., Chaillon, Antoine, Huynh, Christina, Smith, Davey M., Gianella, Sara
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343035/
https://ncbi.nlm.nih.gov/pubmed/30670613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02268-18
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