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A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme
Alterations in the exonuclease domain of DNA polymerase ε (Polε) cause ultramutated tumors. Severe mutator effects of the most common variant, Polε-P286R, modeled in yeast suggested that its pathogenicity involves yet unknown mechanisms beyond simple proofreading deficiency. We show that, despite pr...
Shranjeno v:
| izdano v: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6343027/ https://ncbi.nlm.nih.gov/pubmed/30670691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08145-2 |
| Oznake: |
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