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The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study

AIMS/HYPOTHESIS: The extent to which effects of BMI on CHD are mediated by glycaemic and lipid risk factors is unclear. In this study we examined the effects of these traits using genetic evidence. METHODS: We used two-sample Mendelian randomisation to determine: (1) the causal effect of BMI on CHD...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Xu, Lin, Borges, Maria Carolina, Hemani, Gibran, Lawlor, Debbie A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342872/
https://ncbi.nlm.nih.gov/pubmed/28889241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4396-y
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