Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease

In Alzheimer’s disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment. By the time even the earliest clinical symptoms are detectable, Aβ accumulat...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Lucey, Brendan P., McCullough, Austin, Landsness, Eric C., Toedebusch, Cristina D., McLeland, Jennifer S., Zaza, Aiad M., Fagan, Anne M., McCue, Lena, Xiong, Chengjie, Morris, John C., Benzinger, Tammie L.S., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342564/
https://ncbi.nlm.nih.gov/pubmed/30626715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau6550
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