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Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease
In Alzheimer’s disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment. By the time even the earliest clinical symptoms are detectable, Aβ accumulat...
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| Publicado no: | Sci Transl Med |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6342564/ https://ncbi.nlm.nih.gov/pubmed/30626715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aau6550 |
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