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Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting

Extensive cell-to-cell variation exists even among putatively identical cells, and there is great interest in understanding how the properties of transcription relate to this heterogeneity. Differential expression from the two gene copies in diploid cells could potentially contribute, yet our abilit...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Symmons, Orsolya, Chang, Marcello, Mellis, Ian A., Kalish, Jennifer M., Park, Jihwan, Suszták, Katalin, Bartolomei, Marisa S., Raj, Arjun
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342324/
https://ncbi.nlm.nih.gov/pubmed/30625149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007874
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