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Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis

We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall. It catalyzes the condensation of farnesyl pyrophosphate (FPP) w...

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Détails bibliographiques
Publié dans:Front Microbiol
Auteurs principaux: Jukič, Marko, Rožman, Kaja, Sova, Matej, Barreteau, Hélène, Gobec, Stanislav
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339874/
https://ncbi.nlm.nih.gov/pubmed/30692977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.03322
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