Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants

Cystic fibrosis is caused by mutations in the CFTR gene, which are subdivided into six classes. Mutants of classes III and IV reach the cell surface but have limited function. Most class-III and class-IV mutants respond well to the recently approved potentiator VX-770, which opens the channel. We he...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: van Willigen, Marcel, Vonk, Annelotte M, Yeoh, Hui Ying, Kruisselbrink, Evelien, Kleizen, Bertrand, van der Ent, Cornelis K, Egmond, Maarten R, de Jonge, Hugo R, Braakman, Ineke, Beekman, Jeffrey M, van der Sluijs, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6339265/
https://ncbi.nlm.nih.gov/pubmed/30659068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800172
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