Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

Scaffold proteins tether and orient components of a signaling cascade to facilitate signaling. Although much is known about how scaffolds colocalize signaling proteins, it is unclear whether scaffolds promote signal amplification. Here, we used arrestin-3, a scaffold of the ASK1-MKK4/7-JNK3 cascade,...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Perry, Nicole A., Kaoud, Tamer S., Ortega, Oscar O., Kaya, Ali I., Marcus, David J., Pleinis, John M., Berndt, Sandra, Chen, Qiuyan, Zhan, Xuanzhi, Dalby, Kevin N., Lopez, Carlos F., Iverson, T. M., Gurevich, Vsevolod V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338856/
https://ncbi.nlm.nih.gov/pubmed/30591558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819230116
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