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Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters

A major challenge in drug development is the optimization of intestinal absorption and cellular uptake. A successful strategy has been to develop prodrug molecules, which hijack solute carrier (SLC) transporters for active transport into the body. The proton-coupled oligopeptide transporters, PepT1...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Minhas, Gurdeep S., Newstead, Simon
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338836/
https://ncbi.nlm.nih.gov/pubmed/30602453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813715116
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