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Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters
A major challenge in drug development is the optimization of intestinal absorption and cellular uptake. A successful strategy has been to develop prodrug molecules, which hijack solute carrier (SLC) transporters for active transport into the body. The proton-coupled oligopeptide transporters, PepT1...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6338836/ https://ncbi.nlm.nih.gov/pubmed/30602453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813715116 |
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