(E)-N'-Arylidene-2-(4-oxoquinazolin-4(3H)-yl) acetohydrazides: Synthesis and evaluation of antitumor cytotoxicity and caspase activation activity

In our search for novel small molecules activating procaspase-3, we have designed and synthesised a series of novel acetohydrazides incorporating quinazolin-4(3H)-ones (5, 6, 7). Biological evaluation revealed eight compounds with significant cytotoxicity against three human cancer cell lines (SW620...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Huan, Le Cong, Phuong, Cao Viet, Truc, Le Cong, Thanh, Vo Nguyen, Pham-The, Hai, Huong, Le-Thi-Thu, Thuan, Nguyen Thi, Park, Eun Jae, Ji, A Young, Kang, Jong Soon, Han, Sang-Bae, Tran, Phuong-Thao, Nam, Nguyen-Hai
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338265/
https://ncbi.nlm.nih.gov/pubmed/30734614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1555536
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