Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum

Trichloroethylene (TCE)-induced liver toxicity and carcinogenesis is believed to be mediated in part by activation of the peroxisome proliferator-activated receptor α (PPARα). However, the contribution of the two TCE metabolites, dichloroacetate (DCA) and trichloroacetate (TCA) to the toxicity of TC...

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Detaylı Bibliyografya
Yayımlandı:Arch Toxicol
Asıl Yazarlar: Fang, Zhong-Ze, Krausz, Kristopher W., Tanaka, Naoki, Li, Fei, Qu, Aijuan, Idle, Jeffrey R., Gonzalez, Frank J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338077/
https://ncbi.nlm.nih.gov/pubmed/23575800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-013-1053-1
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