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Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity
Adherens junctions (AJs), together with tight junctions (TJs), form an apical junctional complex that regulates intestinal epithelial cell-to-cell adherence and barrier homeostasis. Within the AJ, membrane-bound E-cadherin binds β-catenin, which functions as an essential intracellular signaling mole...
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| Publicado no: | Am J Physiol Gastrointest Liver Physiol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6336945/ https://ncbi.nlm.nih.gov/pubmed/30285466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00087.2018 |
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