Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity

Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene expression. Although they control gene expression mainly post-transcriptionally, chromatin accessibility plays a fundamental role in transcription initiation control...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Tavernelli, Luis Emilio, Motta, Maria Cristina M., Gonçalves, Camila Silva, da Silva, Marcelo Santos, Elias, Maria Carolina, Alonso, Victoria Lucia, Serra, Esteban, Cribb, Pamela
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336821/
https://ncbi.nlm.nih.gov/pubmed/30655631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36718-0
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