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GUT-DERIVED SEROTONIN CONTRIBUTES TO BONE DEFICITS IN COLITIS

Osteoporosis and bone fractures occur at higher frequency in patients with inflammatory bowel disease (IBD), and decreased bone mass is observed in animal models of colitis. Another consistent feature of colitis is increased serotonin (5-HT) availability in the intestinal mucosa. Since gut-derived 5...

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Detalhes bibliográficos
Publicado no:Pharmacol Res
Main Authors: Lavoie, B, Roberts, JA, Haag, MM, Spohn, SN, Margolis, KG, Sharkey, KA, Lian, JB, Mawe, GM
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336528/
https://ncbi.nlm.nih.gov/pubmed/30030171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2018.07.018
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