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Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates

Sulfonamides are synthetic chemotherapeutic agents that work as competitive inhibitors of the di-hydro-pteroate synthase (DHPS) enzyme, encoded by the folP gene. Resistance to sulfonamides is widespread in the clinical setting and predominantly mediated by plasmid- and integron-borne sul1-3 genes en...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Sánchez-Osuna, Miquel, Cortés, Pilar, Barbé, Jordi, Erill, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335563/
https://ncbi.nlm.nih.gov/pubmed/30687297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.03332
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