Integrative Analysis of Genome and Expression Profile Data Reveals the Genetic Mechanism of the Diabetic Pathogenesis in Goto Kakizaki (GK) Rats

The Goto Kakizaki (GK) rats which can spontaneously develop type 2 diabetes (T2D), are generated by repeated inbreeding of Wistar rats with glucose intolerance. The glucose intolerance in GK rat is mainly attributed to the impairment in glucose-stimulated insulin secretion (GSIS). In addition, GK ra...

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Bibliographische Detailangaben
Veröffentlicht in:Front Genet
Hauptverfasser: Meng, Yuhuan, Cui, Ying, Zhang, Wenlu, Fu, Shuying, Huang, Lizhen, Dong, Hua, Du, Hongli
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Genetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335273/
https://ncbi.nlm.nih.gov/pubmed/30687391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00724
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