Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models

The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure macrofilaricidal and microfilaricidal activities of candidate onchocerciasis drugs. The purpose of this study was to assess whether 5 daily sub-...

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Bibliografiske detaljer
Udgivet i:PLoS Negl Trop Dis
Main Authors: Sjoberg, Hanna T., Pionnier, Nicolas, Aljayyoussi, Ghaith, Metuge, Haelly M., Njouendou, Abdel J., Chunda, Valerine C., Fombad, Fanny F., Tayong, Dizzle B., Gandjui, Narcisse V. T., Akumtoh, Desmond N., Chounna, Patrick W. N., Ndzeshang, Bertrand L., Lachaud, Sophie, Tekle, Fetene, Quirynen, Ludo, Engelen, Marc, Baeten, Benny, Steven, Andrew, Ward, Stephen A., Taylor, Mark J., Wanji, Samuel, Turner, Joseph D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334903/
https://ncbi.nlm.nih.gov/pubmed/30650071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006356
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