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Apoptosis of antigen-specific CTLs contributes to low immune response in gut-associated lymphoid tissue post vaccination

The gut-associated lymphoid tissue (GALT) represents a major reservoir of HIV in infected individuals. Vaccines can induce strong systemic immune responses but these have less impact on CD4 T cells activity and numbers in GALT. In this study, we vaccinated mice with an adenovirus vector that express...

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Bibliografiske detaljer
Udgivet i:Vaccine
Main Authors: Shimada, Masaru, Yoshizaki, Shinji, Ichino, Motohide, Klinman, Dennis M., Okuda, Kenji
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334775/
https://ncbi.nlm.nih.gov/pubmed/25066739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.07.046
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