PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression

While the over-expression of tumor suppressor programmed cell death 4 (PDCD4) induces apoptosis, it was recently shown that PDCD4 knockdown also induced apoptosis. In this study, we examined the cell cycle regulators whose activation is affected by PDCD4 knockdown to investigate the contribution of...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Guo, Jing, Ozaki, Iwata, Xia, Jinghe, Kuwashiro, Takuya, Kojima, Motoyasu, Takahashi, Hirokazu, Ashida, Kenji, Anzai, Keizo, Matsuhashi, Sachiko
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6334536/
https://ncbi.nlm.nih.gov/pubmed/30687637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00661
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